Endocrine Abstracts

Introduction: The Autoimmune Polyendocrinopathy Syndromes (APS) comprise 4 clinical subtypes (1–4), APS type 1 is an autosomal recessive disorder caused by mutations in the AIRE (Autoimmune Regulator) gene. It should include at least 2 of the following 3 major criteria: chronic mucocutaneous candidiasis (CMC), hypoparathyroidism (HPT) and adrenal insufficiency (AI) although 50% of patients develop all 3 features, usually before the age of 20 years. In addition, there are ...

Background: Obesity is a disease with disastrous health, social and economic consequence. There is presently a global epidemic of obesity in all age groups and in both developed and developing countries. Understanding the nutrient and chemical sensing mechanisms in the gastro-intestinal tract (GIT) which act to trigger gut hormone release and appetite after food consumption is crucial to be able to devise effective methods to reduce and prevent obesity. Recently, the sweet tas...